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Related Experiment Video

Updated: May 19, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Versatile Nano-Crosslinker Enhanced Injectable Hydrogel Toward Rapid Hemostasis and Efficient Trauma Repair.

Xiaoshuai Peng¹, Fenglei Chen¹, Yunhui Zhang¹

¹Guangdong Provincial Clinical Research Center for Orthopedic Diseases, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, P. R. China.

Advanced Materials (Deerfield Beach, Fla.)

|May 18, 2026

Summary

A novel injectable hydrogel, OSEG, utilizes versatile nano-crosslinkers for rapid hemostasis and enhanced wound healing. This multifunctional material offers improved outcomes in trauma management, especially in resource-limited settings.

Keywords:

hemostasis injectable hydrogel versatile nano‐crosslinker wound repair

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Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

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Last Updated: May 19, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

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Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Published on: November 11, 2022

Area of Science:

Biomaterials Science
Regenerative Medicine
Nanotechnology

Background:

Uncontrolled hemorrhage and infection are leading causes of trauma mortality worldwide.
Current injectable hydrogels have limitations in multifunctionality for complex trauma care.
Resource-scarce environments necessitate advanced trauma management solutions.

Purpose of the Study:

To develop a versatile injectable hydrogel for efficient hemostasis and wound healing.
To engineer novel nano-crosslinkers for enhanced hydrogel properties.
To evaluate the hydrogel's performance in preclinical trauma models.

Main Methods:

Synthesis of ε-polylysine grafted manganese dioxide (EPL-g-MnO2) nano-crosslinkers.
Construction of an injectable hydrogel (OSEG) using EPL-g-MnO2.
In vitro and in vivo evaluation of hemostasis, antibacterial, and pro-healing effects.

Main Results:

OSEG hydrogel demonstrated rapid hemostasis (24.9s in cardiac hemorrhage model).
The hydrogel formed a robust, multifunctional crosslinked network via multiple bond types.
OSEG hydrogel promoted bone regeneration (3.3x increase in bone volume vs. SURGIFLO) in infected cranial defects.

Conclusions:

OSEG hydrogel offers a promising multifunctional platform for synergistic trauma management.
The novel EPL-g-MnO2 nano-crosslinkers enable advanced hydrogel properties.
This approach has potential for improving outcomes in resource-limited trauma care settings.