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Published on: January 26, 2016
Derbesiamides A-E, Cyclic Depsipeptides from Pedobesia sp
Towa Tsukamoto1, Yuki Yamazaki1, Takeaki Hanyuda1
1School of Marine Biosciences, Kitasato University, Sagamihara, Kanagawa 252-0373, Japan.
None:
Bryopsidales green algae harbor diverse secondary metabolites, yet the family Derbesiaceae remains poorly explored. Herein, we report five cyclic depsipeptides, derbesiamides A-E (1-5), from the green alga Pedobesia sp. The planar structures were established by extensive NMR and HRESI-TOFMS analyses. Absolute configurations of the constituent amino acids were mainly determined by Marfey's analysis. The configurations of the two threonine residues in 3 were further resolved by partial hydrolysis coupled with LC-MS/MS analysis and comparison with synthetic diastereomeric peptide fragments. These findings expand the chemical diversity of Derbesiaceae and highlight Pedobesia as a source of distinctive metabolites.
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