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Published on: January 26, 2016
Derbesiamides A-E, Cyclic Depsipeptides from Pedobesia sp.
Towa Tsukamoto1, Yuki Yamazaki1, Takeaki Hanyuda1
1School of Marine Biosciences, Kitasato University, Sagamihara, Kanagawa 252-0373, Japan.
Journal of Natural Products
|May 18, 2026
Summary
Researchers discovered five new cyclic depsipeptides, named derbesiamides A-E, from the green alga Pedobesia sp. This finding expands the known chemical diversity within the Derbesiaceae family of algae.
Area of Science:
- Marine natural products chemistry
- Algal biochemistry
- Organic chemistry
Background:
- Bryopsidales green algae are known for diverse secondary metabolites.
- The Derbesiaceae family within this order is under-explored chemically.
- Algal metabolites are a rich source of novel bioactive compounds.
Purpose of the Study:
- To investigate the secondary metabolites of the green alga Pedobesia sp.
- To identify and characterize novel compounds from the Derbesiaceae family.
- To expand the understanding of chemical diversity in under-explored marine organisms.
Main Methods:
- Structure elucidation using Nuclear Magnetic Resonance (NMR) spectroscopy.
- High-Resolution Electrospray Ionization Time-of-Flight Mass Spectrometry (HRESI-TOFMS) for molecular formula determination.
- Marfey's analysis and LC-MS/MS for determining absolute configurations of amino acid residues.
Main Results:
- Five cyclic depsipeptides, derbesiamides A-E (compounds 1-5), were isolated and identified.
- The planar structures of derbesiamides A-E were fully characterized.
- Absolute configurations of amino acids and specific threonine residues were established.
Conclusions:
- Derbesiamides A-E represent novel cyclic depsipeptides from the genus Pedobesia.
- This study significantly expands the known chemical repertoire of the Derbesiaceae family.
- Pedobesia sp. is identified as a promising source for discovering unique algal metabolites.
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