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Updated: May 19, 2026

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
Published on: August 19, 2015
Research progress and interfacial adhesion mechanisms of oral delivery systems based on natural polymers
Di Zhao1, Zhujun He1, Yue Chen1
1School of Perfume and Aroma Technology, Shanghai Institute of Technology, No. 100 Haiquan Road, Shanghai 201418, China. zhaodi@sit.edu.cn.
Abstract:
Oral mucoadhesive delivery is a significant strategy for drug administration due to its capacity to bypass hepatic first-pass metabolism and enhance drug bioavailability. However, the highly moist environment and frequent mechanical stresses in the mouth present substantial challenges to delivery systems. In this review, the oral environment and principal challenges of delivery systems and mechanisms of oral adhesion are discussed. Then, the oral drug delivery systems based on natural polymers with good biocompatibility as well as their adhesive mechanisms are analyzed. Moreover, the application areas of these systems in prevention and treatment of oral diseases, local targeted therapy of oral cancer, and dental care are summarized. The emerging role of artificial intelligence technologies in the design of delivery systems and diagnostic assistance is also discussed to put forward the intelligent development trend for oral drug administration. This review can provide a theoretical basis and design insights for oral mucoadhesive delivery systems.
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