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Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Healing I: Introduction01:11

Healing I: Introduction

Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Tissue Injury: Inflammation and Repair01:28

Tissue Injury: Inflammation and Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Cellular Injury I: Introduction01:00

Cellular Injury I: Introduction

Cellular injury occurs when a cell cannot maintain homeostasis or adapt to stressors such as hypoxia, toxins, or trauma. Depending on severity and duration, injury may be reversible, allowing recovery, or irreversible, leading to cell death.General Mechanisms of Cell InjuryAlthough causes vary, most cellular injuries arise from a few key mechanisms that disrupt essential functions and often amplify one another. Cell survival depends on the extent and balance of these disturbances.ATP depletion...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Updated: May 19, 2026

Using R, Seurat, and CellChat to Analyze a Single-Cell Transcriptomics Dataset of Mouse Skin Wound Healing
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Using R, Seurat, and CellChat to Analyze a Single-Cell Transcriptomics Dataset of Mouse Skin Wound Healing

Published on: August 1, 2025

Metabolic Transition Windows in Tissue Repair: Timing, Boundary Conditions and Resolution.

Fangyuan Zhu1,2,3, Feixin Liang1,2,3, Sijia Song1,2,3,4

  • 1Department of Oral and Maxillofacial Surgery, College and Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, 530021, China.

Aging and Disease
|May 18, 2026
PubMed
Summary
This summary is machine-generated.

Metabolic reprogramming is key to tissue repair, but its timing and context determine outcomes like regeneration or scarring. Understanding these dynamics is crucial for improving healing processes.

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Area of Science:

  • Cellular and Molecular Biology
  • Regenerative Medicine
  • Metabolic Regulation

Background:

  • Tissue repair involves significant cellular remodeling and metabolic reprogramming.
  • Metabolic shifts like glycolytic upregulation occur after injury but don't predict repair outcomes alone.
  • Divergent repair trajectories (regeneration vs. fibrosis) suggest a need for a time-resolved perspective.

Purpose of the Study:

  • To synthesize recent findings on the link between metabolic flux, chromatin regulation, and cell-state plasticity in tissue repair.
  • To explore how metabolites influence epigenetic modifications and repair pathways.
  • To discuss the role of the immune microenvironment in shaping metabolic conditions for repair.

Main Methods:

  • Literature review synthesizing recent work on metabolic flux and epigenetics.
  • Analysis of metabolites (acetyl-CoA, α-ketoglutarate, lactate) and their association with chromatin remodeling.
  • Comparative analysis across different organ systems (heart, nervous system, lung, liver).

Main Results:

  • Metabolic remodeling's onset, magnitude, and reversibility, along with spatial/niche factors, influence repair trajectories.
  • Specific metabolites impact chromatin remodeling and epigenetic constraints, though context-dependency exists.
  • Immune microenvironments modulate metabolic conditions, affecting repair initiation and resolution.

Conclusions:

  • Organ-specific bottlenecks can limit repair at various stages.
  • Methodological challenges like reliance on proxies and incomplete temporal data complicate causal interpretation.
  • Future research requires longitudinal, stage-resolved analyses with functional endpoints and consideration of microenvironmental context.