A Feasibility Study of Trans-Arterial Chemoembolization as a First-Line Treatment for Locally Advanced Breast Cancer

Area of Science:

• Oncology
• Interventional Radiology

Background:

• Locally advanced breast cancer (LABC) presents a therapeutic challenge.
• Transarterial chemoembolization (TACE) offers a targeted approach for LABC treatment.

Purpose of the Study:

• To assess the feasibility and efficacy of TACE as a first-line treatment for LABC.
• To evaluate local tumor response and survival rates in LABC patients undergoing TACE.

Main Methods:

• Retrospective evaluation of 31 previously untreated LABC patients (Stages III-IV).
• Selective microcatheter TACE targeting tumor-feeding arteries and axillary lymph nodes.
• Angio-CT for drug distribution confirmation; HepaSphere (50-100 µm) for embolization.

Main Results:

• High response rates for primary breast lesions: 19% (1 mo), 48% (2 mo), 79% (6 mo), 70% (12 mo).
• 1 and 2-year survival rates of 87.1% and 67.6%, respectively; median overall survival 29.7 months.
• TACE was well-tolerated with manageable local pain, bleeding, infection, and minor skin reactions.

Conclusions:

• TACE is a safe and effective first-line therapy for LABC.
• The procedure demonstrates significant local tumor control and improved survival outcomes.