Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AI-augmented thyroid scintigraphy for robust classification of disease.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026
Same author

99mTc‑FAPI‑46 Scintigraphy for Staging of Non-Small Cell Lung Carcinoma.

Clinical nuclear medicine·2026
Same author

99mTc-FAPI SPECT/CT Provides Superior Diagnostic Performance to 18F-FDG in Poorly Differentiated Gastric Adenocarcinoma.

Clinical nuclear medicine·2026
Same author

Maximizing diagnostic yield: A systematic review and deep dive into PSMA PET scan protocol variations for prostate cancer.

Seminars in nuclear medicine·2026
Same author

[¹⁷⁷Lu]Lu-FAPI-2286 radioligand therapy in heavily pre-treated patients with advanced breast and gastrointestinal cancers: a single-center retrospective experience.

BMC cancer·2026
Same author

68Ga-PSMA Scintigraphy of Cervicothoracic Ganglioneuroma.

Clinical nuclear medicine·2026

Related Experiment Video

Updated: May 19, 2026

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography
09:57

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography

Published on: January 11, 2020

99mTc-FAPI-46 Scintigraphy in Parotid Mucoepidermoid Carcinoma.

Amin Saber Tanha1, Kamran Aryana1, Siavash Zahed Anaraki2

  • 1Nuclear Medicine Research Center, Mashhad University of Medical Sciences.

Clinical Nuclear Medicine
|May 18, 2026
PubMed
Summary

Fibroblast activation protein (FAP)-targeted imaging with 99mTc-FAPI-46 shows greater disease burden in recurrent mucoepidermoid carcinoma (MEC) than conventional methods. This novel imaging approach offers comprehensive insights, especially when symptoms and standard scans are discordant.

Keywords:
FAPInuclear imagingoncologysalivary gland neoplasmtheranostic

More Related Videos

An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
10:33

An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use

Published on: May 24, 2024

Related Experiment Videos

Last Updated: May 19, 2026

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography
09:57

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography

Published on: January 11, 2020

An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
10:33

An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use

Published on: May 24, 2024

Area of Science:

  • Nuclear Medicine
  • Oncology
  • Radiochemistry

Background:

  • Recurrent mucoepidermoid carcinoma (MEC) poses significant management challenges, particularly with metastatic disease.
  • Conventional imaging modalities may underestimate the true extent of skeletal and extraskeletal metastases in MEC.
  • Accurate staging is crucial for effective palliative care and treatment planning in advanced cancer.

Purpose of the Study:

  • To evaluate the utility of 99mTc-FAPI-46 scintigraphy in assessing metastatic disease extent in a patient with recurrent MEC.
  • To compare the diagnostic yield of FAP-targeted imaging against conventional bone scintigraphy (99mTc-MDP) and clinical presentation.
  • To highlight the potential of 99mTc-FAPI-46 in identifying a greater disease burden and guiding patient management.

Main Methods:

  • Case report of a 58-year-old female patient with recurrent right parotid MEC.
  • Utilized 99mTc-MDP bone scintigraphy and palliative radiotherapy for symptom management.
  • Performed 99mTc-FAPI-46 scintigraphy to assess metastatic disease following discordant clinical and initial imaging findings.

Main Results:

  • 99mTc-MDP bone scintigraphy showed limited skeletal metastases, while palliative radiotherapy provided no symptom relief.
  • 99mTc-FAPI-46 scintigraphy revealed a significantly greater disease burden, including multiple skeletal metastases, pulmonary involvement, and metastatic lymph nodes.
  • The findings from FAP-targeted imaging were more extensive than suggested by conventional methods and clinical symptoms alone.

Conclusions:

  • 99mTc-FAPI-46 scintigraphy demonstrates added value in detecting the full extent of metastatic disease in recurrent MEC.
  • FAP-targeted imaging may provide comprehensive information beyond conventional modalities, especially in cases with discordant findings.
  • This case suggests that 99mTc-FAPI-46 could be a valuable tool for staging and managing advanced MEC.