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Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

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An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use

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Theranostic Application of FAPI in Advanced Laryngeal Squamous Cell Carcinoma: 99mTc-FAPI-46 SPECT/CT Guided

Haniye Elahifard¹, Mohammad Hadi Samadi¹, Mohsen Saberifar²

¹Mashhad University of Medical Sciences, Nuclear Medicine Research Center, Mashhad, Iran.

Clinical Nuclear Medicine

|May 18, 2026

Summary

This study shows that fibroblast activation protein (FAPI) imaging accurately detects advanced laryngeal cancer spread. FAPI-based radioligand therapy offers a promising theranostic approach for managing metastatic disease.

Keywords:

FAPI laryngeal cancer squamous cell carcinoma theranostic tumor burden

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Published on: January 11, 2020

Area of Science:

Oncology
Nuclear Medicine
Radiochemistry

Background:

Advanced laryngeal squamous cell carcinoma (LSCC) presents significant treatment challenges, often with metastatic spread.
Chemotherapy may be insufficient for controlling widespread skeletal metastases in advanced LSCC.
Accurate staging and monitoring of disease burden are crucial for effective patient management.

Purpose of the Study:

To evaluate the utility of 99mTc-FAPI-46 SPECT/CT for staging advanced LSCC with skeletal metastases.
To assess the theranostic potential of 177Lu-FAPI-2286 radioligand therapy in a patient with advanced LSCC and metastatic disease.

Main Methods:

A patient with advanced LSCC and skeletal metastases underwent 99mTc-FAPI-46 SPECT/CT imaging.
The patient received 177Lu-FAPI-2286 radioligand therapy as part of a clinical trial for palliative management.
Post-treatment imaging was performed to assess tracer accumulation.

Main Results:

99mTc-FAPI-46 SPECT/CT accurately identified the primary laryngeal tumor, cervical involvement, and extensive skeletal metastases.
FAPI uptake correlated with known disease sites, reflecting the overall tumor burden.
Post-therapy imaging confirmed 177Lu-FAPI-2286 accumulation in all disease sites.

Conclusions:

FAPI-based imaging is a valuable tool for staging and monitoring advanced laryngeal carcinoma.
FAPI-based radioligand therapy demonstrates theranostic potential for managing metastatic LSCC.
This approach may improve palliative care and treatment outcomes for patients with advanced laryngeal cancer.