[Current use of statins in antitumor therapy in elderly and senile patients.]

Nowadays, despite advances in curation, multimodal treatments are vastly needed to improve clinical outcomes and overall survival in terms of current incidence and prevalence of cancer. Recent studies have shown that statins belong to a class of drugs known for their potent inhibition of cholesterol production and are commonly prescribed for high blood cholesterol treatment. There is an ongoing growing interest in the use of statins for the treatment of malignant tumors, often in combination with chemotherapy and radiation therapy. Statins, well-known for their pleiotropic effects, can suppress cancer growth by reducing the availability of cholesterol, a key factor in cell proliferation. This review examines their potential use in treatment of breast, colorectal, lung, prostate, and kidney cancer in elderly and geriatric patients, and discusses their primary mechanisms of action.