Related Experiment Videos
Low-Molecular-Weight Fraction of Ripe Pu-erh Tea Protects against Alcohol-Induced Gastric Injury via Gut
Sibo Zhao1,2, Jielin Jiang1,2,3,4, Mianhong Xu1,2
1Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, College of Food Science, Southwest University, Chongqing 400715, China.
None:
Excessive alcohol intake is a major cause of acute alcoholic gastric injury (AGI), yet effective dietary preventive strategies remain limited. Here, ripe Pu-erh tea extract was fractionated into three membrane-separated fractions (T1-T3) and evaluated in preventive and therapeutic mouse models of AGI. The low-molecular-weight fraction T3 (<300 kDa), obtained using a 50 nm ceramic membrane, exhibited the strongest gastroprotective activity, with preventive efficacy exceeding therapeutic efficacy, highlighting the value of early intervention. Preventive T3 administration alleviated gastric mucosal injury, restored PGE2 levels, attenuated inflammation and oxidative stress, and improved intestinal barrier function. These effects were accompanied by gut microbiota remodeling, including enrichment of Dubosiella and Bifidobacterium and increased butyrate production. Antibiotic-mediated microbiota depletion attenuated T3 efficacy, supporting a microbiota-dependent mechanism. Serum metabolomics further indicated regulation of glutathione-related pathways. Overall, T3 represents a promising low-molecular-weight fraction of Pu-erh tea for dietary prevention of AGI through modulation of microbiota-gut-stomach homeostasis.
Related Concept Videos
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
Microbiota of the Stomach and Small Intestine
Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
Microbes in Beverage Production
Peptic Ulcer Disease II: Pathophysiology
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...