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Related Concept Videos

Phosphodiester Linkages01:01

Phosphodiester Linkages

Overview
Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
Phosphodiester Bonds Link Nucleotides Together
DNA and RNA are polynucleotides or long chains of nucleotides that are linked together. A nucleotide is...
Types of Step-Growth Polymers: Polyesters01:20

Types of Step-Growth Polymers: Polyesters

The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
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Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Ion Exchange01:17

Ion Exchange

Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or basic...
Polymer Classification: Stereospecificity01:26

Polymer Classification: Stereospecificity

Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...

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Updated: May 20, 2026

Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

Synthetic Poly(phosphoester)s with Defined Charge Patterns.

Georgette Obeid1, Laurence Charles2, Jean-François Lutz1

  • 1Université de Strasbourg, CNRS, ISIS, 8 Allée Gaspard Monge, 67000 Strasbourg, France.

ACS Macro Letters
|May 18, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed a new method to control charge distribution in sequence-defined poly(phosphodiester)s using specialized monomers. This allows for precise synthesis of polymers with tailored ionic or methylated phosphate sequences, enhancing their structural stability.

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Area of Science:

  • Polymer Chemistry
  • Organic Synthesis
  • Materials Science

Background:

  • Sequence-defined poly(phosphodiester)s are inherently polyanionic due to charged phosphate units.
  • Controlling charge distribution in these polymers is crucial for advanced applications.

Purpose of the Study:

  • To introduce a novel method for precise control over charge distribution in poly(phosphodiester)s.
  • To synthesize polymers with defined sequences of ionic and methylated phosphates.

Main Methods:

  • Solid-phase phosphoramidite chemistry utilizing two non-natural monomers with distinct phosphorus protecting groups (cyanoethyl and methyl).
  • Optimization of solid-phase synthesis conditions, including oxidation and cleavage steps, for selective deprotection.
  • Characterization using ion-exchange HPLC and mass spectrometry.

Main Results:

  • Successful synthesis of oligomers and polymers with precisely controlled charge patterns.
  • Demonstrated selective deprotection of cyanoethyl units.
  • Confirmed formation of macromolecules with well-defined charge distributions.
  • Exhibited robust structural stability in aqueous environments.

Conclusions:

  • The developed method enables precise control over charge distribution in sequence-defined poly(phosphodiester)s.
  • This precise control opens avenues for designing polymers with tailored properties.
  • The synthesized polymers show excellent stability, suitable for various applications.