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It is essential to understand how structural members behave under plastic deformation when the bending stress exceeds the material's yield strength. This state of deformation permanently alters the shape of the member, in contrast to the linear elastic behavior observed before yielding. The strain at any point in the member is expressed in terms of maximum strain. Notably, the neutral axis, which coincides with the centroid during elastic bending, shifts away from the centroid under plastic...
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Updated: May 20, 2026

Examining Changes in HRV and Emotion Following Artmaking with Three Different Art Materials
06:24

Examining Changes in HRV and Emotion Following Artmaking with Three Different Art Materials

Published on: January 11, 2020

Assisted reproductive technology failures.

Laura Rienzi1, Dominique de Ziegler2

  • 1IVIRMA Global Research Alliance, IVRMA Italy, Rome, Italy; University of Urbino, Department of Biomolecular Sciences, Urbino, Italy.

Fertility and Sterility
|May 18, 2026
PubMed
Summary
This summary is machine-generated.

Assisted reproductive technologies (ART) face failures despite advancements. This review examines biological and clinical factors causing ART failures to improve future success rates.

Keywords:
Assisted reproductive failuresIVF failuresfailure to respond to stimulation

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Area of Science:

  • Reproductive medicine
  • Infertility research
  • Clinical embryology

Background:

  • Assisted reproductive technologies (ART) have significantly advanced, improving success rates for infertility treatment.
  • Despite progress, recurrent implantation failures and treatment cancellations remain a challenge in ART.
  • Understanding the root causes of ART failures is crucial for optimizing patient outcomes.

Purpose of the Study:

  • To comprehensively review biological and clinical factors contributing to assisted reproductive technology failures.
  • To assess the predictive value of identified factors on the success of future ART attempts.
  • To explore potential strategies for improving ART outcomes and reducing failure rates.

Main Methods:

  • Systematic literature review of studies on assisted reproductive technology failures.
  • Analysis of biological factors (e.g., gamete quality, uterine environment).
  • Evaluation of clinical factors (e.g., protocols, patient characteristics).

Main Results:

  • Identified key biological factors include oocyte quality, sperm parameters, and endometrial receptivity.
  • Clinical factors such as stimulation protocols, laboratory procedures, and patient age significantly influence ART success.
  • Specific factors demonstrate varying predictive values for future ART attempt success.

Conclusions:

  • ART failures are multifactorial, involving complex interactions between biological and clinical elements.
  • Tailoring treatment strategies based on individual patient profiles and identified risk factors can enhance ART success.
  • Further research is needed to refine predictive models and develop targeted interventions for ART failure.