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Related Experiment Video

Updated: May 20, 2026

Gene Editing of Primary Rhesus Macaque B Cells
09:53

Gene Editing of Primary Rhesus Macaque B Cells

Published on: February 10, 2023

Proteomic Studies in Rhesus Nonhuman Primates Administered a Promising Radiation Medical Countermeasure under

Alana D Carpenter, Issa Melendez Miranda, Yaoxiang Li

    Radiation Research
    |May 18, 2026
    PubMed
    Summary
    This summary is machine-generated.

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    BBT-059, a novel interleukin-11 analog, shows a good safety profile for radiation medical countermeasures. Proteomic analysis in nonhuman primates revealed a robust acute-phase response with no significant adverse effects, supporting its further development for hematopoietic acute radiation syndrome.

    Area of Science:

    • Biomedical Sciences
    • Pharmacology
    • Proteomics

    Background:

    • BBT-059 is a PEGylated interleukin-11 (IL-11) analog with hematopoietic-promoting and anti-apoptotic properties.
    • It is a potential medical countermeasure (MCM) for hematopoietic acute radiation syndrome (H-ARS).
    • Previous studies established BBT-059 efficacy in murine and nonhuman primate (NHP) models.

    Purpose of the Study:

    • To evaluate the safety profile of BBT-059 in nonhuman primates (NHPs).
    • To understand the mechanism of action of BBT-059 through proteomic analysis.
    • To assess dose-dependent effects of BBT-059.

    Main Methods:

    • Twelve naïve NHPs were administered single subcutaneous doses of BBT-059 (37.5, 75, or 150 µg/kg).
    • Serum samples were analyzed using trapped ion mobility spectrometry time-of-flight mass spectrometry (timsTOF-MS).

    Related Experiment Videos

    Last Updated: May 20, 2026

    Gene Editing of Primary Rhesus Macaque B Cells
    09:53

    Gene Editing of Primary Rhesus Macaque B Cells

    Published on: February 10, 2023

  • Proteomic analyses assessed protein, pathway, and dose-dependent changes over 21 days.

    • Main Results:

    • Statistically significant time-dependent proteomic changes were observed post-administration, peaking at 3 days and returning to baseline by study end.
    • BBT-059 triggered an acute-phase response, increasing platelet and neutrophil counts.
    • Activation of neutrophil degranulation and platelet activation, signaling, and aggregation pathways was noted.

    Conclusions:

    • BBT-059 demonstrates a favorable safety profile in NHPs.
    • The observed proteomic response suggests a mechanism involving platelet and neutrophil activation.
    • These findings support the further development of BBT-059 as a radiation MCM for H-ARS.