Dermatophytes: Global Pandemic, Multidrug Resistance, Human-to-Human, and Sexual Transmission.

Area of Science:

• Mycology
• Infectious Diseases
• Epidemiology

Background:

• Dermatophytosis is typically a mild infection of skin, hair, or nails.
• The epidemiology of dermatophytosis is undergoing significant changes.
• New pathogens are emerging from the zoophilic Trichophyton mentagrophytes complex.

Purpose of the Study:

• To highlight the emergence of Trichophyton indotineae and T. mentagrophytes ITS genotype VII as significant human pathogens.
• To discuss the implications of antifungal resistance, particularly to terbinafine and itraconazole.
• To address the challenges in diagnosing and managing these new dermatophyte infections.

Main Methods:

• Observational analysis of epidemiological trends.
• Review of clinical case studies and resistance patterns.
• Assessment of diagnostic and treatment challenges.

Main Results:

• Trichophyton indotineae is a major cause of widespread, severe infections in the Indian subcontinent, often resistant to standard antifungals.
• Terbinafine and itraconazole resistance are significant concerns with global healthcare implications.
• Outbreaks of sexually transmissible T. mentagrophytes ITS genotype VII have been reported, altering transmission understanding.

Conclusions:

• The emergence of drug-resistant dermatophytes like T. indotineae and T. mentagrophytes ITS genotype VII requires a paradigm shift in management.
• Limited diagnostic capacity challenges effective treatment decision-making.
• Advocacy and collaborative efforts are crucial for addressing this evolving public health issue.