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BBB dynamics: the lifespan perspective
1Department of Neurosurgery, McGovern School of Medicine, University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX, 77030, USA. Xuefang.ren@uth.tmc.edu.
Scientific Reports
|May 18, 2026
Summary
The blood-brain barrier (BBB) is a dynamic system that changes throughout life, from development to aging. Understanding its evolution is key for effective drug delivery and preventing neurological disorders.
Area of Science:
- Neuroscience
- Vascular Biology
- Pharmacology
Background:
- The blood-brain barrier (BBB) was traditionally viewed as a static protective barrier.
- Recent research reveals the BBB is a dynamic system with properties changing across the lifespan.
- These dynamics impact central nervous system (CNS) drug exposure and neurological conditions.
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