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Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT

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Published on: May 2, 2017

How organs react under fasting or glucose-insulin status: a self-controlled study using ¹⁸F-FDG total-body PET/CT.

Yifei Tang^1,2,3,4, Yunze Xie^1,2,3,4, Taoying Gu^1,2,3,4

¹Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

European Journal of Nuclear Medicine and Molecular Imaging

|May 18, 2026

Summary

Patients with ischemic cardiomyopathy and diabetes show altered glucose metabolism and impaired inter-organ networks. Non-diabetic patients exhibit more significant metabolic shifts and enhanced connectivity.

Keywords:

Diabetes mellitus Glucose metabolism Inter-organ connectivity Metabolic network Total-body PET/CT

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Published on: January 24, 2025

Area of Science:

Nuclear medicine and metabolic imaging
Cardiovascular disease research
Systemic metabolism

Background:

Ischemic cardiomyopathy (ICM) affects cardiac function and systemic metabolism.
Understanding organ-specific glucose metabolism is crucial for managing ICM.
Diabetes mellitus (DM) further complicates metabolic alterations in ICM.

Purpose of the Study:

To investigate organ-specific glucose metabolism in ICM patients.
To analyze inter-organ metabolic network alterations under fasting and glucose/insulin loading.
To compare metabolic responses between diabetic and non-diabetic ICM patients.

Main Methods:

Prospective, self-controlled study using total-body ¹⁸F-FDG PET/CT scans.
Measurement of SUV_mean in 24 predefined regions of interest (ROIs) under fasting (FAST) and glucose/insulin (G/I) conditions.
Assessment of metabolic network connectivity using mutual information analysis, stratified by DM status.

Main Results:

Non-DM patients showed significant decreases in peripheral and brain glucose uptake and enhanced metabolic network connectivity from FAST to G/I.
DM patients exhibited blunted glucose uptake changes and disrupted metabolic network connectivity, with impaired brain-peripheral interactions.
Smoking and older age correlated with stronger inter-organ connectivity in both DM and non-DM groups.

Conclusions:

Organ-specific metabolic profiles and inter-organ networks differ between fasting and glucose/insulin loading states in ICM.
Diabetic ICM patients display attenuated metabolic responses and network changes compared to non-diabetic patients.
Metabolic network alterations in ICM are influenced by diabetes status, age, and smoking.