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Updated: May 20, 2026

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

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Published on: January 13, 2019

Biomedicine and Biotechnology in Space: An Introduction.

Mariano Bizzarri¹

¹Department BeSSA - Wellbeing, Health and Environmental Sustainability, Head of the National Space Biomedicine Laboratory, Systems Biology Group, Sapienza University of Rome, Rome, Italy. mariano.bizzarri@uniroma1.it.

Methods in Molecular Biology (Clifton, N.J.)

|May 18, 2026

Summary

Human adaptation to spaceflight requires monitoring astronaut health. Clinical pathology aims to identify biological "fingerprints" for preventative health strategies in space.

Keywords:

Omics technologies, Laboratory medicine in space Spaceflight, Biotechnology, Microgravity

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Published on: August 25, 2022

Area of Science:

Space Medicine
Clinical Pathology
Human Physiology

Background:

Human adaptation to spaceflight presents significant physiological and psychological challenges.
Astronauts face extreme conditions including microgravity, radiation, and isolation.
Assessing clinical conditions during space missions is a growing priority.

Purpose of the Study:

To define a strategic analytical approach for clinical pathology in spaceflight.
To identify biological "fingerprints" of complex processes (metabolic, immunologic, genetic).
To develop a comprehensive systemic model for astronaut health and preventative scenarios.

Main Methods:

Developing innovative diagnostic tools and medical devices.
Implementing remote sensing and medical support infrastructures.
Assessing parameters to understand biological pathways and systemic responses.

Main Results:

Identification of key biological markers for spaceflight adaptation.
Establishment of a framework for comprehensive astronaut health assessment.
Potential for predictive health scenarios based on biological data.

Conclusions:

Clinical pathology is crucial for understanding astronaut adaptation to space.
Innovative technologies are essential for remote health monitoring and support.
A systemic approach to biological data can enhance astronaut safety and mission success.