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Updated: May 20, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
Life's Essential 8, genetic susceptibility, and risk of cognitive impairment: results from an elder population-based
Yutong Wang1,2, Bowen Lei1, Ke Jiang1
1West China Institute of Preventive and Medical Integration for Major Diseases, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Introduction:
The American Heart Association's Life's Essential 8 (LE8) framework has been linked to cognitive impairment, but evidence in Chinese older adults remains limited.
Methods:
This cross-sectional study included 7469 adults aged ≥60 years from the West China Health and Aging Cohort. Modified Poisson regression with robust error variance was used to examine the associations of LE8 scores and genetic risk, as well as their joint associations, with cognitive impairment.
Results:
Compared with the low LE8 score group, the high LE8 score group had a prevalence ratio (PR) of 0.65 (95% confidence interval [CI]: 0.56 to 0.76) for cognitive impairment. A joint association was observed between LE8 and genetic risk, with the highest PR of 1.19 (95% CI: 1.12 to 1.27) in the low LE8 and high-genetic-risk group.
Discussion:
Optimal cardiovascular health was associated with lower cognitive impairment and attenuation of genetic risks among older adults in western China.
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