Related Experiment Video

Updated: May 20, 2026

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

Outcomes of Multivessel Percutaneous Coronary Intervention in Diabetic and Non-Diabetic Patients

Syed Tahir Shah1, Syed Muzammil Shah1

  • 1Department of Cardiology, Kuwait Teaching Hospital, Peshawar, Pakistan.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|May 19, 2026
PubMed

Insights

Multivessel percutaneous coronary intervention (PCI) improved angina, ejection fraction (EF), and dyspnoea in both diabetic and non-diabetic patients. However, outcomes were consistently better for non-diabetic individuals, indicating a need for tailored strategies.

Area of Science:

  • Cardiology
  • Interventional Cardiology

Background:

  • Coronary artery disease (CAD) affects millions globally, with diabetes mellitus being a significant risk factor.
  • Multivessel CAD requires effective revascularization strategies, such as percutaneous coronary intervention (PCI).
  • Assessing the impact of diabetes on PCI outcomes is crucial for patient management.

Purpose of the Study:

  • To compare the effectiveness of multivessel PCI in patients with and without diabetes.
  • To evaluate improvements in angina, ejection fraction (EF), and dyspnoea post-PCI.
  • To identify factors influencing PCI outcomes in diabetic versus non-diabetic patients.

Main Methods:

  • An observational study conducted in Peshawar, Pakistan, from January 2020 to December 2022.
  • Included 500 patients (250 diabetic, 250 non-diabetic) with multivessel CAD undergoing PCI.
  • Assessed CCS angina grade, EF, and NYHA dyspnoea classification at 1, 3, 6, and 12 months post-procedure using statistical analyses including t-tests and regression.

Main Results:

  • Diabetic patients presented with more severe disease (higher angina, lower EF) than non-diabetic patients.
  • Non-diabetic patients showed significantly greater improvements in angina grade and EF post-PCI.
  • Dyspnoea reduction was similar between groups; diabetes independently predicted reduced treatment efficacy, particularly in younger patients.

Conclusions:

  • Multivessel PCI improves cardiovascular outcomes in both diabetic and non-diabetic patients with multivessel CAD.
  • Non-diabetic patients consistently achieve better outcomes following PCI compared to diabetic patients.
  • Tailored revascularization strategies and further research are essential to optimize PCI outcomes for diabetic patients.
Abstract

Related Concept Videos

Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Complications of Diabetes Mellitus01:22

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...