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Global trends in minipuberty research: A comprehensive bibliometric analysis
Yi Jiang1, Kaiqin Jin2, Wen Zhong3
1Department of General Medicine, Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, China.
Medicine
|May 19, 2026
Summary
Minipuberty research has significantly expanded over two decades, shifting towards molecular mechanisms and long-term outcomes. This bibliometric analysis maps the evolving global research landscape and collaborations in this critical developmental window.
Area of Science:
- Pediatric Endocrinology
- Reproductive Biology
- Bibliometrics
Background:
- Minipuberty involves transient activation of the hypothalamic-pituitary-gonadal axis postnatally.
- The global research on minipuberty has not been systematically mapped.
- Understanding this critical window is essential for developmental health.
Purpose of the Study:
- To conduct a comprehensive bibliometric analysis of minipuberty research.
- To delineate the evolving research landscape, collaborative networks, and thematic shifts over two decades.
- To identify key trends and future directions in minipuberty research.
Main Methods:
- Bibliometric analysis of 201 articles published between 2003 and 2025 from Web of Science Core Collection.
- Utilized Bibliometrix, VOSviewer, and CiteSpace for data analysis.
- Examined publication trends, country/institution contributions, co-authorship, and keyword dynamics.
Main Results:
- Significant increase in publications after 2013, peaking in 2024.
- Denmark and the United States are leading countries; University of Copenhagen is the top institution.
- Research themes evolved from basic fertility studies to endocrine disruption, therapeutics, and genetic regulation.
Conclusions:
- Minipuberty research has transitioned from descriptive studies to translational science.
- Emerging trends focus on molecular mechanisms and long-term developmental outcomes.
- Future research should emphasize longitudinal studies, advanced techniques, and interdisciplinary collaboration.
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