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Related Experiment Video

Updated: May 20, 2026

Ex Vivo Culture of Circulating Tumor Cells in the Cerebral Spinal Fluid from Melanoma Patients to Study Melanoma-Associated Leptomeningeal Disease
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Radiologic-pathologic correlation in meningeal melanocytosis: A case report.

Dong Bai1, Fang Li, Zhiqun Wang

  • 1Department of Radiology, Aerospace Center Hospital, Beijing, China.

Medicine
|May 19, 2026
PubMed
Summary
This summary is machine-generated.

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Meningeal melanocytosis is a rare disorder that can mimic other conditions on MRI. Definitive diagnosis often requires leptomeningeal biopsy when other tests are inconclusive.

Area of Science:

  • Neurology
  • Radiology
  • Pathology

Background:

  • Meningeal melanocytosis is a rare leptomeningeal melanocytic disorder.
  • It often mimics meningeal carcinomatosis or chronic meningitis on MRI.
  • This poses significant diagnostic challenges.

Purpose of the Study:

  • To enhance clinical awareness of meningeal melanocytosis.
  • To highlight the importance of radiologic-pathologic correlation.
  • To discuss diagnostic challenges and potential solutions.

Main Methods:

  • A case report of a 19-year-old male with progressive neurological symptoms.
  • Neuroimaging, cerebrospinal fluid analysis, NGS, and PET-CT were non-diagnostic.
  • Stereotactic leptomeningeal biopsy confirmed the diagnosis via histopathology and immunohistochemistry.
Keywords:
case reportleptomeningeal enhancementmelanocytic tumorsmeningeal melanocytosisradiologic–pathologic correlation

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Last Updated: May 20, 2026

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Published on: March 29, 2024

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Main Results:

  • The patient presented with headache, nausea, vomiting, and seizures.
  • Initial investigations and empirical therapy were unsuccessful.
  • Biopsy revealed melanocytic proliferation, confirming meningeal melanocytosis.

Conclusions:

  • Meningeal melanocytosis can present without typical MRI findings.
  • Leptomeningeal biopsy is crucial when noninvasive tests are inconclusive.
  • Susceptibility-weighted imaging and molecular testing may aid early diagnosis.