Reduced Cardiovascular Risk Indicated by Changes in Triglyceride-Glucose Index After Pancreas Transplantation

Area of Science:

• Endocrinology
• Cardiovascular Medicine
• Transplantation Surgery

Background:

• Pancreas transplantation is the primary causal treatment for type 1 diabetes.
• The triglyceride-glucose (TyG) index serves as a validated marker for long-term cardiovascular event risk.
• Assessing cardiovascular risk reduction via the TyG index in pancreas transplant recipients is crucial.

Purpose of the Study:

• To evaluate the potential reduction in cardiovascular risk using the TyG index as a surrogate marker in patients undergoing pancreas transplantation.
• To analyze changes in the TyG index at various time points before and after pancreas transplantation.

Main Methods:

• Retrospective analysis of 86 pancreas transplant recipients.
• Measurement of serum triglyceride and glucose levels at pre-transplant qualification and at 1, 3, 6, and 12 months post-transplant.
• Application of repeated measures ANOVA and mixed models to assess changes in the TyG index over time.

Main Results:

• A statistically significant decrease in the mean TyG index was observed as early as 1 month after transplantation.
• The reduction in the TyG index remained stable throughout the 12-month follow-up period.
• Trend analysis confirmed a significant decrease in the TyG index from pre-transplant to early and late follow-up stages.

Conclusions:

• Pancreas transplantation is associated with a significant reduction in the TyG index in recipients.
• This reduction suggests a potentially lower long-term cardiovascular risk following pancreas transplantation.
• The TyG index can serve as a valuable surrogate marker for cardiovascular risk assessment in pancreas transplant recipients.