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Updated: May 20, 2026
11:14
Modeling Paracrine Noncanonical Wnt Signaling In Vitro
Published on: December 10, 2021
Research Progress of Wnt1-Inducible Signaling Pathway Protein 1 in Human Cancer
Ai-Hong Mao1,2, Xiao-Xi Chen1,2, Hui-Yan Pang1,2
1School of Biological & Pharmaceutical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China.
Summary
Wnt1-inducible signaling pathway protein 1 (WISP1) is crucial in cell functions and disease. Dysregulated WISP1 expression links to various human diseases, making it a potential biomarker and therapeutic target.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Wnt1-inducible signaling pathway protein 1 (WISP1) is a secreted protein in the CCN family.
- WISP1 regulates critical cellular processes like proliferation, differentiation, apoptosis, adhesion, and metastasis.
- Aberrant WISP1 expression is implicated in human diseases, including cancer, fibrosis, metabolic, and cardiovascular disorders.
Purpose of the Study:
- To review the structure, expression, functions, and clinical relevance of WISP1 in human cancers.
- To elucidate the molecular mechanisms of WISP1 in cancer.
- To highlight the translational clinical value of WISP1 in cancer diagnosis and therapy.
Main Methods:
- Literature review of studies on WISP1.
- Analysis of WISP1 structure, expression patterns, and biological functions.
- Examination of clinical correlations and molecular mechanisms of WISP1 in cancer.
Main Results:
- WISP1 plays a significant role in various physiological and pathological processes.
- Dysregulated WISP1 expression is associated with the development and progression of multiple human diseases.
- WISP1 shows potential as a diagnostic/prognostic biomarker and therapeutic target in cancer.
Conclusions:
- WISP1 is a key player in cellular functions and disease pathogenesis.
- Understanding WISP1's role is vital for developing novel cancer diagnostics and therapeutics.
- WISP1 holds significant translational value for clinical applications in oncology.
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