Plants and Plant-Derived Compounds Mediate Protection Across Diverse Pathological Conditions by Targeting the
Fatemeh Yarmohammadi1, Seyed Shahram Miraghaee2, Gholamreza Karimi3,4
1Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.
Phytotherapy Research : PTR
|May 19, 2026
Summary
Herbal medicines and natural compounds can modulate PANoptosis, a programmed cell death pathway implicated in various diseases. These natural products suppress key molecular drivers of PANoptosis, offering therapeutic potential for inflammatory and organ injury conditions.
Area of Science:
- Immunology
- Cell Biology
- Pharmacology
Background:
- PANoptosis is an inflammatory programmed cell death pathway integrating pyroptosis, apoptosis, and necroptosis.
- It is crucial for innate immunity but its dysregulation contributes to diseases like sepsis, cancer, and organ injuries.
- Targeting PANoptosis is a promising therapeutic strategy.
Purpose of the Study:
- To review the effects of herbal medicines and bioactive compounds on PANoptosis.
- To explore their potential as therapeutic agents for diseases linked to PANoptosis.
Main Methods:
- Literature review of preclinical evidence on herbal medicines and compounds modulating PANoptosis.
- Analysis of their effects on core molecular drivers (caspases, RIPK1/3, MLKL, GSDMD, NLRP3) and pathways (ZBP1, cytokines, Nrf2).
Main Results:
- Numerous plant-derived compounds and traditional formulations suppress key PANoptosis molecular drivers.
- Mechanisms include downregulating upstream sensors, reducing pro-inflammatory cytokines, and enhancing antioxidant defenses (Nrf2, SOD, CAT).
- Natural products show protective potential in models of cardiovascular, pulmonary, renal, hepatic, and neurological diseases.
Conclusions:
- Herbal medicines and their compounds effectively modulate PANoptosis pathways.
- These natural products offer a promising therapeutic avenue for various diseases associated with PANoptosis dysregulation.
- Further research into these natural agents could lead to novel treatments for inflammatory and degenerative conditions.
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