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Related Concept Videos

Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for their...
Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
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Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

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Related Experiment Video

Updated: May 20, 2026

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
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Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

Gabapentin and Pregabalin Overdoses and Their Management: An Update.

Canan Akman1, Asli Bahar Ucar2, Asim Bedri Erdem3

  • 1Department of Emergency Medicine, Canakkale Onsekiz Mart University, Canakkale, Türkiye.

Current Pharmaceutical Design
|May 19, 2026
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Summary

Gabapentinoids like gabapentin and pregabalin offer benefits for pain management but carry risks. Prescribers must carefully weigh pros and cons, especially in high-risk patients, to ensure safe and effective use.

Keywords:
Gabapentinadverse effectsgabapentinoidsneuropathic painoverdosepoisoningpregabalinsafety.

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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Published on: August 16, 2018

Related Experiment Videos

Last Updated: May 20, 2026

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
07:16

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

Area of Science:

  • Pharmacology and Therapeutics
  • Pain Management
  • Drug Safety

Background:

  • Gabapentinoids (gabapentin, pregabalin) are increasingly prescribed for neuropathic pain, fibromyalgia, and neuralgia.
  • Their use has grown significantly in recent decades worldwide.
  • Understanding their benefits and risks is crucial for effective clinical application.

Purpose of the Study:

  • To review the advantages and disadvantages of gabapentinoids (gabapentin and pregabalin).
  • To highlight advancements and areas for improvement in gabapentinoid therapy.
  • To compare gabapentinoids with opioids and other pain management alternatives.

Main Methods:

  • Systematic literature search (2005-2025) in major databases (PubMed, Scopus, Web of Science, etc.).
  • Focused on effectiveness and safety profiles of gabapentin and pregabalin.
  • Excluded editorials, expert opinions, and retrospective studies.

Main Results:

  • Gabapentinoids have shown efficacy in reducing opioid prescription rates.
  • Pregabalin prescriptions increased linearly, often co-prescribed with opioids (over 25%).
  • Fatalities primarily involved concurrent use of gabapentinoids with other substances, particularly opioids.

Conclusions:

  • Despite wider recognition, gabapentinoids possess inherent hazards requiring clinician awareness.
  • Guidelines should address the risk-benefit profile of gabapentinoids versus opioids for diverse patient groups.
  • Vigilant monitoring for misuse and abuse is essential, especially in high-risk populations.