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Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
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An Overview: New Trends in Synthetic Methods and Pharmaceutical Applications of Pyrrole-Derivatives

Nonkululeko H Zulu1, Adewale O Adeloye1,2, David S Khanye3

  • 1Department of Chemistry, School of Science, College of Science, Engineering & Technology, University of South Africa, Florida, Johannesburg, South Africa.

Current Medicinal Chemistry
|May 19, 2026
PubMed

Keywords:
Pyrrolecancer therapiesgreen synthesismedicinal applicationsmetallacrown pyrrolemetalpyrroles.

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Heterocyclic aromatic compounds are cyclic compounds that are aromatic and have one or more heteroatoms—atoms other than carbon, in the ring. Depending upon the number of atoms present in the ring, they can be either five or six-membered. Examples of five-membered heterocyclic aromatic compounds include pyrrole, furan, thiophene, and imidazole. Pyrrole consists of one nitrogen atom having one lone pair of electrons. Furan and thiophene have one oxygen and one sulfur heteroatom, respectively.
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