Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Microbial Corrosion

Microbial Corrosion

Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...

Chemical Agents for Microbial Control

Chemical Agents for Microbial Control

Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...

Antimicrobial Proteins

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...

Antimicrobial Effectiveness

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...

Antidotes

Antidotes

Antidotes are medicinal substances used to counteract the harmful effects of toxins or drugs in the body. They function in various ways, each uniquely designed to combat specific toxic compounds.
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...

Clinical Significance of Antibiotic Resistance

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cobalt complexes in biology and medicine: enzymatic functions, pharmacological applications, and health challenges.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry·2026

Same author

The emerging potential of gallium compounds in medical research: A promising frontier.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)·2025

Same author

Synthesis, docking, pharmacokinetic prediction, and acetylcholinesterase inhibitory evaluation of <i>N</i>-(2-(piperidine-1-yl)ethyl)benzamide derivatives as potential anti-Alzheimer agents.

Research in pharmaceutical sciences·2025

Same author

Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review.

Journal of cancer research and clinical oncology·2024

Same author

Anti-quorum sensing effects of SidA protein on <i>Escherichia coli</i> receptors: <i>in silico</i> analysis.

Journal of biomolecular structure & dynamics·2024

Same author

Synthesis, in silico studies, and in vitro biological evaluation of newly-designed 5-amino-1<i>H</i>-tetrazole-linked 5-fluorouracil analog as a potential antigastric-cancer agent.

Journal of biomolecular structure & dynamics·2024

Search research articles

Related Experiment Video

Updated: May 20, 2026

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

Nickel-based Enzymes and Compounds: Antimicrobial Potential, Biomedical Applications, and Toxicity Risks.

Sara Abdolmaleki¹, Alireza Aliabadi^2,3, Rasoul Motahari⁴

¹Department of Pharmaceutical Chemistry, School of Science and Technology, The University of Georgia, Tbilisi, Georgia.

Mini Reviews in Medicinal Chemistry

|May 19, 2026

Summary

Nickel-dependent enzymes are vital for microbial life and offer new ways to fight antibiotic-resistant bacteria. Nickel compounds show antibacterial potential but require careful use due to toxicity concerns.

Keywords:

Nickel-dependent enzymes antibacterial agent nickel complexes nickel metal-organic frameworks (Ni- MOFs)nickel nanoparticles (NiNPs)toxicity of nickel.

More Related Videos

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects

Published on: September 27, 2024

Related Experiment Videos

Last Updated: May 20, 2026

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects

Published on: September 27, 2024

Area of Science:

Biochemistry
Microbiology
Materials Science

Background:

Nickel-dependent enzymes are crucial metalloenzymes in various organisms, particularly microbes.
Nine such enzymes involved in redox and non-redox reactions are known.
These enzymes are targets for new strategies against antibiotic-resistant bacteria.

Purpose of the Study:

To review nickel-based compounds, their enzymatic roles, and biological functions.
To analyze antimicrobial mechanisms and applications of nickel compounds.
To assess the associated toxicities of nickel compounds in medical and dental contexts.

Main Methods:

Systematic compilation and analysis of current literature.
Focus on enzymatic roles, biological functions, and antimicrobial mechanisms.
Evaluation of medical/dental applications and toxicological profiles.

Main Results:

Nickel-dependent enzymes like hydrogenases and urease are key targets for combating resistant bacteria.
Synthetic nickel nanoparticles, complexes, and MOFs exhibit antibacterial properties via nickel ion release.
Nickel compounds can disrupt bacterial membranes and metabolism, inducing oxidative stress and ROS formation.

Conclusions:

Nickel-based compounds offer promising antibacterial strategies, particularly against resistant strains.
Clinical use of nickel alloys requires monitoring due to potential allergic reactions and oxidative damage.
Nickel's dual nature necessitates careful management to balance essential trace requirements against toxicity risks.