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Neutrophilic Panniculitis in a Pediatric Patient Receiving Ponatinib

Jessica S Hathaway1, Alejandro A Gru2, Laura E Levin2

  • 1Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.

Pediatric Dermatology
|May 19, 2026
PubMed

Insights

Ponatinib, a leukemia treatment, can cause neutrophilic panniculitis in children. This case highlights the need to consider this rare adverse event in pediatric patients.

Area of Science:

  • Pediatric Hematology Oncology
  • Dermatology
  • Pharmacology

Background:

  • Ponatinib is a tyrosine kinase inhibitor (TKI) used for chronic myeloid leukemia (CML).
  • Adverse events associated with TKIs in pediatric populations require ongoing investigation.
  • Neutrophilic panniculitis is an inflammatory skin condition characterized by neutrophil infiltration of subcutaneous fat.

Keywords:
drug eruptionimmunomodulating agentsneutrophilic panniculitisponatinibtyrosine kinase inhibitors

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