Related Experiment Video
Updated: May 20, 2026
13:04
Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
Published on: March 18, 2015
PCI after SVG failure-native vessel or graft?
1Department of Cardiac Surgery, Rabindranath Tagore International Institute of Cardiac Sciences, Narayana Health, 124, EM Bypass, Mukundapur, Kolkata, 700099 India.
Summary
Percutaneous coronary intervention (PCI) of saphenous vein grafts (SVG) showed better outcomes than native vessel PCI in a recent trial. This challenges current guidelines recommending native vessel intervention for SVG failure after bypass surgery.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Clinical Trials
Background:
- Saphenous vein graft (SVG) failure is a common complication after coronary artery bypass grafting (CABG).
- Re-intervention is often necessary, but treatment strategies remain debated.
- Current guidelines suggest prioritizing percutaneous coronary intervention (PCI) of the native coronary artery over SVG-PCI.
Purpose of the Study:
- To compare the efficacy and safety of SVG-PCI versus native coronary artery PCI in patients with prior CABG and SVG failure.
- To provide evidence to inform treatment guidelines for SVG failure.
Main Methods:
- The PROCTOR trial was a randomized controlled trial.
- It compared SVG-PCI directly with native coronary artery PCI.
- Outcomes were assessed at 1-year follow-up.
Main Results:
- SVG-PCI demonstrated significantly lower rates of major adverse cardiac events (MACE) at 1 year compared to native vessel PCI.
- This suggests SVG-PCI may be a superior re-intervention strategy in select patients.
Conclusions:
- The PROCTOR trial findings challenge existing guideline recommendations.
- SVG-PCI may be a favorable option for re-intervention in SVG failure.
- Longer-term follow-up data are needed to confirm these results.
