Related Experiment Video
Updated: May 20, 2026
06:08
Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions
Published on: March 8, 2019
The association between gut microbiome and aortic aneurysm: a review article
Sidharth Misra1, Zainab Yusufali Motiwala2, Aditya Puniyani1
1Armed Forces Medical College, Pune, India.
Summary
The gut microbiome influences aortic aneurysm development by affecting inflammation and immune responses. Modulating gut bacteria offers potential new strategies for preventing and treating aortic aneurysms.
Area of Science:
- Cardiovascular Research
- Microbiome Research
- Immunology
Background:
- Aortic aneurysm (AA) pathogenesis is linked to traditional risk factors like atherosclerosis, hypertension, and diabetes.
- Emerging evidence highlights the gut microbiome's significant role in AA development.
- Understanding this connection is crucial for novel therapeutic approaches.
Purpose of the Study:
- To explore the intricate relationship between the gut microbiome and aortic aneurysm.
- To synthesize current knowledge on the gut microbiome's influence on AA pathogenesis.
- To identify research gaps in the gut microbiome-AA axis.
Main Methods:
- Comprehensive literature review utilizing PubMed, Embase, and Google Scholar.
- Critical evaluation and analysis of relevant studies.
- Narrative summarization of existing evidence.
Main Results:
- Gut dysbiosis (microbial imbalance) promotes systemic inflammation and alters immune responses, contributing to vascular wall degeneration.
- Bacterial metabolites, including short-chain fatty acids (SCFAs), modulate inflammatory pathways.
- Microbial translocation exacerbates oxidative stress, further promoting aneurysm formation.
Conclusions:
- The gut microbiome-aortic aneurysm axis is a critical factor in AA pathogenesis.
- Targeting the gut microbiome presents promising avenues for innovative AA prevention and treatment strategies.
- Further research into this axis can lead to novel therapeutic interventions.
Related Concept Videos
01:30Aneurysm I: Introduction
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
01:22Gut-Brain Axis
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
01:26Aneurysm III: Interprofessional Care
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
01:27The Oral Microbiota
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
01:15Aortic Regurgitation I: Introduction
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...