Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 20, 2026

Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid

Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid

Published on: September 27, 2024

Post-Market Observational Study of Injectable PLLA Microspheres for Facial Rejuvenation.

Dario Bertossi¹, Alessandra Camporese², Nicola Kefalas³

¹Section of Oral and Maxillofacial Surgery, Department of Surgical Sciences, University of Verona, Verona, Italy.

Clinical, Cosmetic and Investigational Dermatology

|May 19, 2026

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Stand-Alone Carboxytherapy Followed by Consolidation with Oral Hydrolyzed Marine Collagen Fragments: A Potential Sequential Bioregenerative Strategy for Hypertrophic Scars: A Case Report.

International medical case reports journal·2026

Same author

Psychosocial Outcomes and Aesthetic Expectations in Female Patients Undergoing Body Contouring After GLP-1-Induced Weight Loss: A Prospective Pilot Comparative Study with Post-Bariatric Patients.

Aesthetic plastic surgery·2026

Same author

Ultrasound imaging in aesthetic medicine: safety and precision in injectable procedures.

Journal of ultrasound·2026

Same author

Ozone in Botulinum Toxin-Induced Ptosis: Some Comments.

Journal of cosmetic dermatology·2026

Same author

The Combined Benefits of Definisse™ Revitalise Threads and Definisse [KP1]<sup>®</sup> Redensifying Cream Treatments: A 19-Patient Case Series.

Life (Basel, Switzerland)·2026

Same author

First Insights on the Upcoming Role of Next-Generation PLLA-LASYNPRO in Aesthetic and Regenerative Medicine: A Survey of Experts-the PLLA-LASYNPRO Rationale.

Facial plastic surgery : FPS·2026

Poly-L-lactic acid (PLLA) microspheres effectively improved facial aging and skin conditions, with high patient satisfaction and minimal side effects. This injectable bio-regenerator offers natural, sustained aesthetic enhancement.

Area of Science:

Dermatology
Aesthetic Medicine
Regenerative Medicine

Background:

Facial aging and skin conditions impact quality of life, driving demand for aesthetic treatments.
Poly-L-lactic acid (PLLA) microspheres are utilized for aesthetic facial rejuvenation.

Purpose of the Study:

To investigate the efficacy and safety of PLLA microspheres (PLLA-LASYNPRO™) in patients with chronoaging, photoaging, and various facial skin conditions.
To assess patient satisfaction and physician-evaluated aesthetic improvement following PLLA-LASYNPRO™ treatment.

Main Methods:

An observational study involving 95 adult patients treated with PLLA-LASYNPRO™ for aging and skin conditions.
Patient-reported outcomes via questionnaires and physician assessments using the Global Aesthetic Improvement Scale (GAIS).

Keywords:

PLLA collagen stimulation facial rejuvenation poly-L-lactic acid real-world evidence regenerative aesthetics skin quality

More Related Videos

Mechanical Micronization of Lipoaspirates for Regenerative Therapy

Mechanical Micronization of Lipoaspirates for Regenerative Therapy

Published on: March 15, 2019

Related Experiment Videos

Last Updated: May 20, 2026

Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid

Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid

Published on: September 27, 2024

Mechanical Micronization of Lipoaspirates for Regenerative Therapy

Mechanical Micronization of Lipoaspirates for Regenerative Therapy

Published on: March 15, 2019

Documentation through 2D and 3D imaging, with adverse event monitoring.

Main Results:

100% of patients showed physician-assessed GAIS improvement, with 94.7% reporting high satisfaction.
Visible improvements in skin texture, firmness, and elasticity were noted after the first session and progressed over time.
Only mild, transient adverse events like swelling and discomfort were reported, resolving spontaneously.

Conclusions:

PLLA-LASYNPRO™ is a safe, effective, and well-tolerated injectable bio-regenerator for facial aesthetic improvement.
The treatment yields natural, gradual, and sustained enhancements in skin quality and facial contour.
High patient satisfaction and compliance were observed, particularly for the middle and lower face.