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Genetically Encoded Tools To Monitor And Interrogate Membrane Contact Sites.

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Genetically Encoded Tools To Monitor And Interrogate Membrane Contact Sites.

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Split-Luciferase Reassembly Assay to Measure Endoplasmic Reticulum-Mitochondria Contacts in Live Cells

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Published on: October 11, 2024

Genetically Encoded Tools to Monitor and Interrogate Membrane Contact Sites.

Yuepeng Ke¹, Tien-Hung Lan¹, Thomas Ahn¹

¹Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA.

Contact (Thousand Oaks (Ventura County, Calif.))

|May 19, 2026

View abstract on PubMed

Summary

This summary is machine-generated.

New molecular tools like proximity-based reporters and optogenetics allow researchers to visualize and control membrane contact sites (MCSs). These advancements aid in understanding organelle communication and may lead to new therapies.

Keywords:

cellsignaling chemically induced proximity chemogenetics membrane contact sties (MCSs)optogenetics proximity-based labeling

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Split-Luciferase Reassembly Assay to Measure Endoplasmic Reticulum-Mitochondria Contacts in Live Cells

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Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy

Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy

Published on: March 5, 2017

Area of Science:

Cell Biology
Molecular Biology
Biophysics

Background:

Membrane contact sites (MCSs) are crucial for cellular functions like signaling and metabolism.
Understanding MCS regulation requires tools for precise spatial and temporal monitoring.

Purpose of the Study:

To review recent advances in molecular tools for studying membrane contact sites.
To highlight the applications of these tools in dissecting MCS biology.

Main Methods:

Development of proximity-based reporters.
Application of chemogenetic and optogenetic systems.
Protein engineering for enhanced spatial and temporal control.

Main Results:

Engineered tools enable visualization and manipulation of MCSs with high precision.
These tools provide new insights into inter-organelle communication.
Demonstrated applications in studying diverse MCS functions.

Conclusions:

Advanced molecular toolkits are essential for interrogating MCSs.
These tools offer novel approaches to understand organelle crosstalk.
Future therapeutic strategies may target MCSs based on these findings.