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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
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Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...

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Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
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Occurrence and Progression Risk of Uveitic Glaucoma.

Ikuyo Sada1, Keita Kihara1,2, Tomona Hiyama1

  • 1Department of Ophthalmology and Visual Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.

Ocular Immunology and Inflammation
|May 19, 2026
PubMed
Summary

Glaucoma is prevalent in Japanese uveitis patients, particularly with chronic anterior forms. Increased intraocular pressure fluctuation may indicate faster visual field loss in uveitic glaucoma.

Keywords:
Intraocular pressuresecondary glaucomauveitic glaucomauveitisvisual field

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Area of Science:

  • Ophthalmology
  • Immunology

Background:

  • Uveitis is a significant cause of vision loss.
  • Glaucoma is a common complication of uveitis, but its prevalence and risk factors in specific populations require further investigation.

Purpose of the Study:

  • Determine the prevalence of glaucoma in adult Japanese patients with uveitis.
  • Assess glaucoma comorbidity based on uveitis etiology and classification.
  • Investigate the relationship between intraocular pressure fluctuation and uveitic glaucoma progression.

Main Methods:

  • Retrospective analysis of 671 adult Japanese uveitis patients (≥20 years) from July 2009 to June 2023.
  • Data collection included uveitis etiology, anatomical classification, uveitic glaucoma (UG) presence, and glaucoma surgery.
  • Disease progression (mean deviation slope) analyzed against intraocular pressure (IOP) fluctuation (standard deviation of IOP measurements).

Main Results:

  • Glaucoma (UG) was present in 31.6% of patients, with chronic uveitis in 93.9%.
  • Anterior uveitis was most common (34.4%). Non-infectious causes (86.3%) included idiopathic, sarcoidosis, and Vogt-Koyanagi-Harada disease.
  • High glaucoma comorbidity observed in sarcoidosis (50.0%) and Cytomegalovirus (CMV) anterior uveitis (77.8%). Greater IOP fluctuation showed a negative correlation with visual field progression.

Conclusions:

  • Glaucoma is frequently associated with chronic and anterior uveitis in Japanese adults.
  • Specific conditions like sarcoidosis, Vogt-Koyanagi-Harada disease, and CMV anterior uveitis exhibit high glaucoma comorbidity.
  • Increased intraocular pressure fluctuation may predict faster visual field deterioration in uveitic glaucoma.