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Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications

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Published on: February 23, 2017

Advanced High-Entropy Biomaterials (HEBs).

Xiaowen Wang¹, Siyu Zhou¹, Jiangling Zhu¹

¹School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai, China.

Small (Weinheim an Der Bergstrasse, Germany)

|May 19, 2026

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High-entropy biomaterials (HEBs) offer unique properties for advanced biomedical applications. This review covers HEBs

Area of Science:

Materials Science
Biomedical Engineering
Nanotechnology

Background:

High-entropy materials (HEMs) feature multi-principal elements, leading to unique effects like high-entropy and lattice distortion.
These effects grant HEMs exceptional mechanical, catalytic, and multifunctional properties beneficial for biomedicine.
The application of HEMs in biomedicine, termed high-entropy biomaterials (HEBs), is rapidly growing but lacks comprehensive review.

Purpose of the Study:

To provide a comprehensive review of high-entropy biomaterials (HEBs) and their biomedical applications.
To elucidate the fundamental characteristics of HEBs, linking their core effects to physicochemical properties.
To discuss future challenges and opportunities in HEB development and clinical translation.

Main Methods:

Keywords:

antimicrobial interventions anti‐inflammatory treatment biosensing bone tissue engineering high‐entropy materials tumor therapy

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Literature review and synthesis of recent advances in high-entropy biomaterials.
Analysis of the fundamental principles governing HEBs, including entropy, lattice distortion, diffusion, and cocktail effects.
Categorization and discussion of current and emerging biomedical applications of HEBs.

Main Results:

HEBs exhibit tunable properties derived from their unique composition and core effects.
Key applications include bone tissue engineering, vascular stents, tumor therapy, anti-inflammatory treatments, antimicrobial strategies, and biosensing.
The review highlights the significant potential of HEBs across diverse biomedical fields.

Conclusions:

HEBs represent a promising class of materials for advanced biomedical applications due to their tunable properties.
Future research should focus on biosafety evaluations and integrating computational tools for rational HEB design.
Accelerating clinical translation requires addressing challenges in design, manufacturing, and regulatory approval.