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Updated: May 20, 2026

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
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Advanced High-Entropy Biomaterials (HEBs).

Xiaowen Wang1, Siyu Zhou1, Jiangling Zhu1

  • 1School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai, China.

Small (Weinheim an Der Bergstrasse, Germany)
|May 19, 2026
PubMed
Summary
This summary is machine-generated.

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High-entropy biomaterials (HEBs) offer unique properties for advanced biomedical applications. This review covers HEBs

Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Nanotechnology

Background:

  • High-entropy materials (HEMs) feature multi-principal elements, leading to unique effects like high-entropy and lattice distortion.
  • These effects grant HEMs exceptional mechanical, catalytic, and multifunctional properties beneficial for biomedicine.
  • The application of HEMs in biomedicine, termed high-entropy biomaterials (HEBs), is rapidly growing but lacks comprehensive review.

Purpose of the Study:

  • To provide a comprehensive review of high-entropy biomaterials (HEBs) and their biomedical applications.
  • To elucidate the fundamental characteristics of HEBs, linking their core effects to physicochemical properties.
  • To discuss future challenges and opportunities in HEB development and clinical translation.

Main Methods:

Keywords:
antimicrobial interventionsanti‐inflammatory treatmentbiosensingbone tissue engineeringhigh‐entropy materialstumor therapy

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  • Literature review and synthesis of recent advances in high-entropy biomaterials.
  • Analysis of the fundamental principles governing HEBs, including entropy, lattice distortion, diffusion, and cocktail effects.
  • Categorization and discussion of current and emerging biomedical applications of HEBs.

Main Results:

  • HEBs exhibit tunable properties derived from their unique composition and core effects.
  • Key applications include bone tissue engineering, vascular stents, tumor therapy, anti-inflammatory treatments, antimicrobial strategies, and biosensing.
  • The review highlights the significant potential of HEBs across diverse biomedical fields.

Conclusions:

  • HEBs represent a promising class of materials for advanced biomedical applications due to their tunable properties.
  • Future research should focus on biosafety evaluations and integrating computational tools for rational HEB design.
  • Accelerating clinical translation requires addressing challenges in design, manufacturing, and regulatory approval.