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Related Experiment Video

Updated: May 20, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
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Published on: June 23, 2023

Calcitonin Gene-Related Peptide Signalling in Alcohol Use Disorders: A Scoping Review.

Lanfranco Pellesi1, Taibah Ali Ahmad1, Simona Guerzoni2

  • 1Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.

Drug and Alcohol Review
|May 19, 2026
PubMed
Summary

Calcitonin gene-related peptide (CGRP) influences alcohol use disorder (AUD) mechanisms, impacting stress and withdrawal. CGRP shows protective effects against alcohol-induced injury, suggesting a complex therapeutic role.

Keywords:
addictioncravingheadachemigrainepain

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Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

Area of Science:

  • Neuroscience
  • Pharmacology
  • Gastroenterology

Background:

  • Alcohol use disorders (AUD) pose a significant global health challenge with limited treatment efficacy.
  • Calcitonin gene-related peptide (CGRP) is a neuropeptide involved in stress and neuroimmune signaling, with established roles in migraine treatment.
  • Emerging evidence suggests CGRP signaling pathways may be implicated in alcohol-related mechanisms.

Purpose of the Study:

  • To conduct a scoping review of original studies examining the role of CGRP and related pathways in alcohol exposure and AUDs.
  • To synthesize preclinical and clinical findings on CGRP's involvement in alcohol-related behaviors and pathologies.

Main Methods:

  • Systematic literature search across major databases (PubMed, Embase, Cochrane Library, PsycINFO, Scopus).
  • Inclusion of original animal and human studies investigating CGRP in the context of alcohol.
  • Narrative synthesis of findings from 30 included studies (26 animal, 4 human).

Main Results:

  • Preclinical data indicate CGRP modulates stress-related drinking and withdrawal, but does not directly drive alcohol consumption.
  • CGRP demonstrates protective effects against ethanol-induced gastric and pulmonary injury in peripheral tissues.
  • Limited human studies suggest altered CGRP biology in advanced alcohol-related liver disease, potentially indicating a homeostatic role.

Conclusions:

  • CGRP is a complex target in AUDs, with context-dependent therapeutic and protective roles.
  • Anti-CGRP therapies might be considered for specific conditions like alcohol-related headache or withdrawal symptoms in non-cirrhotic patients.
  • Cautious evaluation of pharmacological CGRP modulation is recommended due to its homeostatic functions.