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Related Concept Videos

Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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From Precision to Personalized: Catalyzing AI-Enabled Innovation in Drug Development.

Adarsh Subbaswamy1, Allison Dunn1, Brooke Langevin1

  • 1Center for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, Maryland, USA.

Clinical and Translational Science
|May 19, 2026
PubMed
Summary
This summary is machine-generated.

The Precision Medicine Initiative aimed to revolutionize healthcare through individualized care. This analysis explores the impact of this initiative on patient treatments over the past decade.

Keywords:
artificial intelligencedrug developmentpersonalized medicineprecision medicineregulatory science

Related Experiment Videos

Area of Science:

  • Genomics and Bioinformatics
  • Translational Medicine
  • Health Policy

Background:

  • The Precision Medicine Initiative, launched in 2015, sought to advance personalized healthcare.
  • It emphasized collaboration between patients, researchers, and providers.
  • The initiative aimed to foster a new era of individualized medical care.

Purpose of the Study:

  • To evaluate the evolution of patient treatments since the Precision Medicine Initiative's inception.
  • To assess the impact of precision medicine on clinical practice and patient outcomes.
  • To analyze the progress in research, technology, and policy supporting individualized care.

Main Methods:

  • Literature review of studies published post-2015 focusing on precision medicine.
  • Analysis of treatment guideline changes and adoption of targeted therapies.
  • Examination of technological advancements in genomic sequencing and data analysis.

Main Results:

  • Increased availability of targeted therapies based on genetic profiles.
  • Growth in genomic data utilization for clinical decision-making.
  • Emergence of new research cohorts and data-sharing platforms.

Conclusions:

  • Precision medicine has demonstrably influenced treatment landscapes.
  • Continued advancements in technology and data integration are crucial.
  • The initiative has laid groundwork for more personalized patient care.