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Updated: May 20, 2026

Implementation of Minimally Invasive Brain Tumor Resection in Rodents for High Viability Tissue Collection

Implementation of Minimally Invasive Brain Tumor Resection in Rodents for High Viability Tissue Collection

Published on: May 9, 2022

Prognostic Validation of the RANO-Resect Classification and Non-Contrast-Enhancing Tumor Resection: A Meta-Science

Pavel S Pichardo-Rojas¹, Diego Pichardo-Rojas², Diana Ochoa-Hernandez³

¹Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, New York, New York, USA.

|May 19, 2026

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Maximal safe resection of glioblastoma (GBM) improves survival. The RANO-resect classification offers a standardized, reproducible method for assessing extent of resection, outperforming inconsistent non-standardized definitions.

Area of Science:

Neurosurgery
Oncology
Radiology

Background:

Maximal safe resection is crucial for glioblastoma (GBM) patient survival.
Standardized classification for extent of resection (EOR), especially beyond contrast-enhancing (CE) tumor, is inconsistent.
The Response Assessment in Neuro-Oncology (RANO)-resect classification shows prognostic value but needs comparative validation.

Purpose of the Study:

Evaluate the prognostic performance of the RANO-resect classification for EOR in GBM.
Compare the reproducibility of RANO-resect in survival estimation against alternative non-standardized definitions.
Assess the impact of resecting non-CE tumor on patient outcomes.

Main Methods:

Systematic literature search for studies on GBM surgery using RANO-resect classification and evaluating non-CE tumor resection.

Keywords:

Glioblastoma RANO-resect Supramaximal resection Supratotal resection

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Last Updated: May 20, 2026

Implementation of Minimally Invasive Brain Tumor Resection in Rodents for High Viability Tissue Collection

Implementation of Minimally Invasive Brain Tumor Resection in Rodents for High Viability Tissue Collection

Published on: May 9, 2022

Meta-analysis of 17 studies (n=2606) to compare survival outcomes based on RANO-resect classes and non-CE tumor resection.

Assessment of heterogeneity in survival estimates across different classification methods.

Main Results:

Higher RANO-resect volumetric classes (Class 1-4) significantly correlated with improved overall survival (OS) and progression-free survival (PFS).
Resection of non-CE tumor improved OS (6.4 months) and PFS (5.2 months) compared to CE tumor resection alone.
The RANO-resect Class 1 definition showed minimal heterogeneity (I2=0%) in OS outcomes, unlike alternative definitions (40%-74%).

Conclusions:

Maximal volumetric resection of non-CE tumor improves survival in newly diagnosed GBM.
The RANO-resect classification provides more homogeneous and predictable survival estimates than non-standardized definitions.
RANO-resect classification demonstrates potential for implementation in future clinical trials for standardized EOR assessment.