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Related Concept Videos

DNA Bacteriophages01:26

DNA Bacteriophages

Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
Viral Replication: Lysogenic Cycle01:16

Viral Replication: Lysogenic Cycle

The lysogenic cycle is a crucial viral replication strategy that allows bacteriophages to persist within host cells without immediately destroying them. This process is primarily observed in temperate phages, such as bacteriophage lambda (λ), which infects Escherichia coli. The cycle allows the viral genome to persist across bacterial generations while keeping host cells viable.Integration of the Viral GenomeUpon infection, bacteriophage lambda attaches to the bacterial surface and injects its...
Lytic Cycle of Bacteriophages01:30

Lytic Cycle of Bacteriophages

Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the lytic replication...
Viral Replication: Lytic Cycle01:20

Viral Replication: Lytic Cycle

Bacteriophages, or phages, are viruses that specifically infect bacteria. Among them, T-even bacteriophages, such as T4, exhibit a well-characterized lytic replication cycle in Escherichia coli (E. coli). This process ensures the rapid proliferation of the virus while ultimately leading to the destruction of the bacterial host.Attachment and DNA InjectionThe infection process begins with the recognition and binding of the T4 phage to the E. coli cell surface. Tail fibers of the phage...
Lysogenic Cycle of Bacteriophages00:43

Lysogenic Cycle of Bacteriophages

In contrast to the lytic cycle, phages infecting bacteria via the lysogenic cycle do not immediately kill their host cell. Instead, they combine their genome with the host genome, allowing the bacteria to replicate the phage DNA along with the bacterial genome. The incorporated copy of the phage genome is called the prophage. Some prophages can re-activate and enter the lytic cycle. This often occurs in response to a perturbation, such as DNA damage, but can also transpire in the absence of...
Transduction01:16

Transduction

Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome are...

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Updated: May 20, 2026

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
09:40

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

A polyvalent phage shapes bacterial dynamics.

Cristian V Crisan1,2, Daria Van Tyne3, Joanna B Goldberg1,2

  • 1Department of Pediatrics, Division of Pulmonary, Asthma, Cystic Fibrosis, and Sleep, Emory University School of Medicine, Atlanta, Georgia, USA.

Journal of Virology
|May 19, 2026
PubMed
Summary
This summary is machine-generated.

Polyvalent phages like PSA39 significantly impact bacterial populations, reducing both Pseudomonas aeruginosa and Stenotrophomonas maltophilia. Pseudomonas aeruginosa adapts, while Stenotrophomonas maltophilia survival is impaired, with both evolving pili gene mutations for resistance.

Keywords:
Pseudomonas aeruginosaStenotrophomonas maltophiliabacterial dynamicspolyvalent bacteriophages

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Last Updated: May 20, 2026

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
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Published on: June 11, 2015

Following Cell-fate in E. coli After Infection by Phage Lambda
06:10

Following Cell-fate in E. coli After Infection by Phage Lambda

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T4 Bacteriophage and E. coli Interaction in the Murine Intestine: A Prototypical Model for Studying Host-Bacteriophage Dynamics In Vivo
08:46

T4 Bacteriophage and E. coli Interaction in the Murine Intestine: A Prototypical Model for Studying Host-Bacteriophage Dynamics In Vivo

Published on: January 26, 2024

Area of Science:

  • Microbiology
  • Virology
  • Ecology

Background:

  • Bacteria and bacteriophages (phages) are key microbial ecosystem members.
  • Antagonistic interactions influence microbial population dynamics.
  • Polyvalent phages infect multiple bacterial species, but their ecological role is understudied.

Purpose of the Study:

  • Investigate the impact of polyvalent phage PSA39 on co-cultured Pseudomonas aeruginosa and Stenotrophomonas maltophilia.
  • Understand how polyvalent phages alter dynamics in co-existing bacterial populations.

Main Methods:

  • Co-culturing experiments with P. aeruginosa, S. maltophilia, and phage PSA39.
  • Quantifying bacterial recovery and phage titers.
  • Analyzing bacterial evolution and genetic mutations.

Main Results:

  • PSA39 significantly reduced both bacterial populations, with a stronger effect on S. maltophilia.
  • P. aeruginosa adapted to PSA39, while S. maltophilia survival was impaired in co-culture.
  • Both bacterial species evolved mutations in pili genes to resist PSA39 lysis.
  • Higher viral titers were observed when propagating with S. maltophilia.

Conclusions:

  • Polyvalent phages can significantly alter bacterial community structure and dynamics.
  • P. aeruginosa and S. maltophilia with PSA39 serve as a model for studying polyvalent phage impacts.
  • Bacterial resistance to polyvalent phages can involve mutations in pili genes.