Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Landscape of copy number variants in Spanish people with dementia.

NPJ genomic medicine·2026
Same author

Ill Fate of Rectal Mucinous Adenocarcinoma: A Defect in Immunosurveillance or a Mucin Coating Effect?-The IMMUNOREACT 20 Study.

Cancers·2026
Same author

Serological and Molecular Detection of Zoonotic Pathogens in European Bison (<i>Bison bonasus</i>) and Associated Ticks from Poland.

Pathogens (Basel, Switzerland)·2026
Same author

Seeing beyond white light: fluorescence for safer laparoscopic cholecystectomy.

Frontiers in surgery·2026
Same author

Targeting an RNA Editor to Impede H3K27M+ Pediatric Gliomas.

bioRxiv : the preprint server for biology·2026
Same author

Connecting HTT intermediate alleles and microRNA dysregulation to enhanced tauopathy in late-onset Alzheimer's disease.

Alzheimer's research & therapy·2026

Related Experiment Video

Updated: May 20, 2026

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery
07:14

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery

Published on: January 18, 2018

Association Between CTSG Variants and Persistent Postoperative Pain After Cardiac Surgery.

Nerea García1, Javier Díaz-Arias2, Valentina Chiminazzo3

  • 1From the Anaesthesiology Service, Hospital Universitario Central de Asturias, Oviedo, Spain.

Anesthesia and Analgesia
|May 19, 2026
PubMed
Summary
This summary is machine-generated.

Genetic variations in Cathepsin G (CTSG) influence long-term pain after cardiac surgery. Specific CTSG polymorphisms are associated with reduced or increased postoperative pain susceptibility, impacting patient outcomes.

More Related Videos

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)

Published on: January 27, 2010

Related Experiment Videos

Last Updated: May 20, 2026

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery
07:14

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery

Published on: January 18, 2018

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)

Published on: January 27, 2010

Area of Science:

  • Genetics and Molecular Biology
  • Pain Research
  • Cardiovascular Surgery

Background:

  • Cathepsin G (CTSG), a neutrophil protease, plays a role in inflammatory pain.
  • Genetic variations in CTSG may affect susceptibility to postoperative pain.
  • Understanding CTSG's role is crucial for managing long-term pain after cardiac surgery.

Purpose of the Study:

  • To investigate the association between CTSG gene polymorphisms, plasma concentration, enzymatic activity, and long-term pain after cardiac surgery.
  • To evaluate the influence of specific CTSG single nucleotide polymorphisms (SNPs) on pain outcomes.
  • To explore potential mechanisms linking CTSG to persistent postoperative pain.

Main Methods:

  • Prospective cohort study of 255 Caucasian adults undergoing elective cardiac surgery.
  • Genotyping of CTSG SNPs (rs2070697, rs2236742, rs45567233) and measurement of CTSG plasma concentration and activity in a subsample.
  • Assessment of pain intensity using visual analogue scale (VAS) at multiple time points (24 hours, 1, 6, 12 months).
  • Statistical analysis using ordinal logistic regression and Mendelian randomization.

Main Results:

  • The rs2070697 AA genotype was linked to reduced pain at 1, 6, and 12 months post-surgery.
  • The rs2236742 AA genotype was associated with increased pain at all assessed time points.
  • Lower CTSG activity was observed in rs2070697 A-allele carriers; no causal link between CTSG activity and pain was found.
  • No significant associations were identified for the rs45567233 polymorphism.

Conclusions:

  • Specific CTSG gene variants appear to modulate susceptibility to prolonged pain following sternotomy.
  • These genetic factors may contribute to individual differences in long-term pain after cardiac surgery.
  • Further validation in larger, multi-ethnic cohorts is needed to elucidate mechanisms and guide personalized pain management strategies.