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Associations between quadrant retinal layer thickness and pupillary light reflex in axial myopia
Jian Cao1,2, Yong Ma1,3,4,5, Yongle Bao1,6
1Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.
Summary
Axial myopia affects pupillary light reflex (PLR) dynamics, with axial elongation accelerating dilation but not constriction. Retinal layer thickness influences PLR metrics, particularly in males.
Area of Science:
- Ophthalmology
- Neuroscience
- Physiology
Background:
- Pupillary light reflex (PLR) is crucial for visual function.
- Axial myopia, characterized by increased axial length (AL), is common in young individuals.
- Understanding factors influencing PLR in myopia is important for visual health assessment.
Purpose of the Study:
- To investigate the impact of sex, retinal thickness, and axial length (AL) on the pupillary light reflex (PLR) in young individuals with axial myopia.
Main Methods:
- Sixty-two myopic patients (50% male) were analyzed.
- Axial length (AL) and anterior chamber metrics were measured.
- Swept-source optical coherence tomography (OCT) and pupillometry were used to assess retinal layers and PLR dynamics.
Main Results:
- Males exhibited a weaker peak pupillary constriction ratio than females.
- Maximum constriction velocity correlated positively with ganglion cell-inner plexiform layer (GCIPL) and total retinal thickness.
- Accelerated pupillary dilation time was associated with higher AL and thicker macular retinal nerve fiber layer (mRNFL) in nasal regions.
Conclusions:
- Axial elongation accelerates post-illumination pupillary dilation but does not significantly impact constriction.
- Reduced outer annular GCIPL thickness is linked to slower pupillary constriction velocity.
- Thinning of the nasal mRNFL correlates with prolonged pupillary dilation latency.
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