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Morbidity and Mortality Rates in People with Diabetes Mellitus With an Active Charcot's Neuro-Osteoarthropathy: A

Dipen Patel1, Catherine Gooday1,2,3, Ian Nunney1

  • 1Norwich Medical School, University of East Anglia, Norwich, Norfolk, NR4 7TJ, UK.

Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders
|May 19, 2026
PubMed

Insights

Charcot neuro-osteoarthropathy (CN) in diabetes patients leads to high amputation and mortality risks. Early, aggressive intervention targeting multiple risk factors is crucial for better outcomes in CN patients.

Area of Science:

  • Diabetology
  • Podiatry
  • Vascular Surgery

Background:

  • Diabetes-related Charcot neuro-osteoarthropathy (CN) significantly increases risks of limb amputation and premature death.
  • Understanding risk factors for adverse outcomes in CN is critical for patient management.

Purpose of the Study:

  • To determine amputation and mortality rates in patients with active CN.
  • To identify participant and CN characteristics associated with increased risk of amputation and mortality.

Main Methods:

  • A retrospective, single-center study included 186 participants with active CN and type 1 or type 2 diabetes.
  • Data were collected from January 2007 to September 2022.
  • Participant and CN characteristics were analyzed for associations with amputation or mortality.

Main Results:

  • The 1-, 5-, and 10-year mortality rates were 2.7%, 18.9%, and 40%, respectively.
  • Male sex and prior amputation were linked to higher amputation risk.
  • Prior amputation and worsening chronic kidney disease stage correlated with increased mortality risk.

Conclusions:

  • Patients with active CN face substantial risks of amputation and mortality.
  • Multifactorial causes of death necessitate comprehensive risk factor intervention.
  • Early, aggressive management strategies are recommended to mitigate adverse outcomes in CN patients.
Abstract

Keywords:
AmputationCharcot neuro-osteoarthropathyMortality

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