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Effectiveness of Metabolic and Bariatric Surgery for Patients with Obesity and Asthma: A Systematic Review and
Angel Alois Osorio Manyari1, Azucena Lirio Armas Alvarez2, Joel Davis Osorio Manyari3
1Service of Surgery, Hospital Don Benito-Villanueva, Don Benito, Spain. aloisosorio@hotmail.com.
Abstract:
Obesity is a modifiable risk factor for asthma worldwide and is associated with poor asthma control. Weight loss is an effective intervention for patients with obesity and asthma; however, a consistent association between metabolic bariatric surgery (MBS) and asthma in patients with obesity is lacking. To assess the effects of MBS in patients with obesity and asthma, we conducted a meta-analysis of data from inception to February 2026. Thirty-three observational studies including 3731 patients were analyzed. A total of 47% of patients achieved discontinuation of asthma medication (95% CI, 0.38-0.56; p < 0.05), and 58% of patients achieved clinical asthma remission (95% CI, 0.45-0.70; p < 0.05). Additionally, MBS was associated with an 8.5% increase in forced expiratory volume in one second (FEV1) (95% CI, 4.5-12.6; p < 0.05) and a 9.4% increase in forced vital capacity (FVC) (95% CI, 6.3-12.6; p < 0.05). This evidence suggests that MBS results in clinical remission of asthma and improvement in pulmonary function in patients with obesity and asthma. KEY POINTS: •MBS can alleviate clinical asthma in patients with obesity. •MBS can improve FEV1 in patients with obesity and asthma. •MBS can improve FVC in patients with obesity and asthma.
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