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Published on: August 12, 2020
Eosinophilic Myenteric Ganglionitis in a Newborn: Case Report
Luz F Sua1,2, María Del Mar Conde3, Juan Carlos Bravo1
1Department of Pathology and Laboratory Medicine, Fundación Valle del Lili, Cali, Colombia.
Summary
Eosinophilic myenteric ganglionitis, a rare cause of intestinal pseudo-obstruction, was diagnosed in a newborn with intestinal malrotation. Early diagnosis via comprehensive biopsy is crucial for management and preventing complications.
Area of Science:
- Gastroenterology
- Pediatric Surgery
- Pathology
Background:
- Eosinophilic myenteric ganglionitis (EMG) is a rare condition causing pseudo-obstructive intestinal syndrome, primarily in children.
- It mimics mechanical intestinal obstruction but lacks a visible lesion, identified histologically by eosinophilic inflammation in the myenteric plexus.
Purpose of the Study:
- To report the first case of a newborn with intestinal malrotation and EMG.
- To emphasize the importance of comprehensive intestinal wall biopsy for accurate diagnosis and management.
Main Methods:
- Case report of a male newborn with intestinal obstruction.
- Histological examination revealing eosinophilic infiltrate around colonic ganglion cells.
- Surgical correction of intestinal malrotation with a diverting ileostomy.
Main Results:
- The patient presented with intestinal obstruction, diagnosed with malrotation and EMG.
- Surgical correction led to clinical improvement.
- Follow-up revealed possible rectal motility impairment, suggesting potential long-term functional deficits.
Conclusions:
- This is the first reported case of EMG in a newborn with intestinal malrotation.
- Comprehensive intestinal biopsy is vital for accurate diagnosis of EMG.
- Early diagnosis and management are essential for preventing complications and improving outcomes.
- Further research is needed to better understand, diagnose, and treat EMG.
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