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Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
Published on: August 4, 2022
Contextualizing innovation in addiction psychiatry: opportunities to deliver precision medicine in a complex clinical
Alexander Mario Baldacchino1, Joe Schofield, Gosia Mitka
1St Andrews Systems Innovation Lab for Addiction Care, University of St Andrews, St Andrews, Fife, Scotland, UK.
Purpose Of Review:
Current approaches to preventing drug-related harms remain suboptimal. This review describes components of a systems innovation framework for addiction care designed to address escalating drug-related harms and fragmented service delivery through a multidisciplinary, ecosystem-driven approach.
Recent Findings:
Innovative approaches to addiction medicine are needed that integrate clinical research with entrepreneurial execution to address three priority areas of need: real-time risk mitigation using digital phenotyping and wearable biosensors for overdose detection; precision surveillance utilizing AI-informed data ecosystems and wastewater analysis; and next-generation therapeutics, including neuromodulation and nanotechnology-driven drug delivery. This creates an innovative "biopsychotechnological" treatment paradigm that moves beyond traditional clinical boundaries.
Summary:
This framework provides a roadmap for transitioning addiction care from reactive clinical and risk management to innovative and proactive precision medicine. For research, it necessitates a shift toward interdisciplinary validation of "biopsychotechnological" models that bridge bench science and community implementation. For clinical practice, this framework offers a blueprint for integrating real-time biosensing and advanced therapeutics into patient care, promising to reduce mortality and support sustainable recovery through ecosystem-informed and individualized care.
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