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Published on: January 2, 2013
Clinical Effect Analysis of Frozen-Thawed-Deglycerolized Red Blood Cells
Yajie Wang1, Quan Rao2, Yiming Ma1
1Department of Blood Transfusion, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Acta Haematologica
|May 19, 2026
Summary
Frozen-thawed-deglycerolized red blood cells (FTD-RBCs) are safe and effective for clinical use. FTD-RBCs can supplement blood supplies during shortages, showing significant increases in RBC count, HGB, and HCT post-transfusion.
Area of Science:
- Transfusion Medicine
- Hematology
Background:
- Blood supply shortages pose significant challenges in healthcare.
- Frozen-thawed-deglycerolized red blood cells (FTD-RBCs) offer a potential solution for extending red blood cell viability and availability.
Purpose of the Study:
- To evaluate the clinical efficacy and safety of transfusing FTD-RBCs.
- To assess the impact of FTD-RBCs on key hematological parameters.
- To determine the utility of FTD-RBCs as a supplement during blood supply shortages.
Main Methods:
- Retrospective study comparing 280 patients receiving FTD-RBCs with 280 patients receiving suspended red blood cells (SRBCs).
- Collected data included transfusion amounts and pre/post-transfusion RBC count, hemoglobin (HGB), and hematocrit (HCT).
- Statistical analysis included Mann-Whitney U test and Kruskal-Wallis H test to compare efficacy and identify adverse reactions.
Main Results:
- FTD-RBC transfusion led to significant increases in RBC count, HGB, and HCT (P<0.05).
- Increments in these parameters were comparable to SRBCs, with no statistically significant difference (P>0.05).
- No adverse transfusion reactions were observed in patients receiving FTD-RBCs. Efficacy varied with patient factors like sex, age, weight, disease, and blood type.
Conclusions:
- FTD-RBCs are a safe and effective option for clinical transfusion.
- FTD-RBCs serve as a valuable supplement to the blood supply, particularly during shortages.
- Patient-specific factors influence the efficacy of FTD-RBC transfusions.
