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Updated: May 21, 2026

Employing Digital Droplet PCR to Detect BRAF V600E Mutations in Formalin-fixed Paraffin-embedded Reference Standard Cell Lines
Published on: October 8, 2015
Association between Clinicopathological Features and BRAF V600E Mutation in Papillary Thyroid Carcinoma: A
Tao Fu1, Jiahao Chen1, Xiaxia Jin2
1The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, China.
Introduction:
The association between BRAF V600E mutation and clinicopathological features of papillary thyroid carcinoma (PTC) remains controversial. This study aimed to explore its prognostic value via meta-analysis.
Methods:
Databases including PubMed, Cochrane Library, Embase, and Web of Science were systematically searched for studies published before June 1, 2025. Pooled odds ratio (OR) with 95% confidence interval (CI) was used as the effect size, analyzed by R 4.4.2.
Results:
A total of 26 studies (2010-2024) involving 13,999 patients were included. BRAF V600E mutation was significantly positively associated with capsular invasion (OR = 1.80, 95% CI: 1.16-2.78) and extrathyroidal extension (OR = 1.62, 95% CI: 1.36-1.94), and negatively associated with concomitant Hashimoto's thyroiditis (OR = 0.55, 95% CI: 0.32-0.94). A marginal association trend was observed with gender, with male patients showing a higher likelihood of harboring the BRAF V600E mutation (OR = 1.26, 95% CI: 1.10-1.44, p = 0.0525), while no significant associations were found with age, tumor size, multifocality, central or lateral lymph node metastasis.
Conclusion:
BRAF V600E mutation correlates with specific clinicopathological features of PTC and serves as a potential prognostic predictor.
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