Related Experiment Video
Updated: May 21, 2026
07:30
Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
[Sepsis: Update 2026]
Lina-Hanne Maria Ko1, Axel Nierhaus1, Stefan Kluge1
1Universitätsklinikum Hamburg-Eppendorf, Klinik für Intensivmedizin, Deutschland, Hamburg.
Pneumologie (Stuttgart, Germany)
|May 19, 2026
Summary
Sepsis management in Germany is improving with updated guidelines recommending NEWS2 for early recognition and prompt antibiotic/fluid therapy. Structured post-sepsis care is emphasized for survivors to address long-term complications.
Area of Science:
- Pulmonology
- Critical Care Medicine
- Infectious Diseases
Background:
- Sepsis is a major cause of in-hospital mortality, particularly affecting the respiratory system.
- Germany faces ~279,000 sepsis cases annually with high mortality rates.
- Timely diagnosis and treatment are crucial for improving sepsis outcomes.
Purpose of the Study:
- To outline updated sepsis management guidelines in Germany.
- To emphasize early recognition, guideline-based therapy, and quality assurance.
- To highlight structured post-sepsis care for survivors.
Main Methods:
- Adoption of the NEWS2 score for sepsis screening.
- Recommendations for early lactate measurement.
- Guidelines for timely antimicrobial administration and hemodynamic stabilization.
Main Results:
- NEWS2 score recommended as a practical alternative to qSOFA.
- Specific timelines for antibiotic initiation in sepsis and septic shock.
- Standardized fluid resuscitation protocols and vasopressor choice (norepinephrine).
Conclusions:
- Updated guidelines aim to enhance sepsis recognition and treatment in Germany.
- Nationwide quality assurance procedures are implemented to improve patient outcomes.
- Structured post-sepsis care, including management of post-intensive care syndrome (PICS), is vital.
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