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Published on: May 5, 2023

Stroke in older adults: exploring the intersections of comorbidity, disability, and frailty

Terence J Quinn1, Nicholas Evans2, Patricia Fearon3

  • 1School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK.

The Lancet. Healthy Longevity
|May 19, 2026
PubMed

Insights

Stroke predominantly affects older adults. Key factors like comorbidity, disability, and frailty significantly impact stroke care and outcomes, necessitating tailored approaches across the entire patient journey.

Area of Science:

  • Gerontology
  • Neurology
  • Public Health

Background:

  • Stroke disproportionately affects older adults, making age-related complexities crucial for effective care.
  • Understanding the interplay between aging, comorbidity, disability, and frailty is essential for optimizing stroke management.
  • Current stroke care pathways may not adequately address the unique needs of older adults.

Purpose of the Study:

  • To review the impact of comorbidity, disability, and frailty on stroke care in older adults.
  • To provide guidance on assessing these age-related factors in stroke patients.
  • To explore innovative approaches for improving stroke care across the continuum for older individuals.

Main Methods:

  • Literature review focusing on cerebrovascular disease epidemiology in aging populations.
  • Analysis of the bidirectional relationship between aging factors and stroke.
  • Examination of stroke care from prevention through post-acute phases.

Main Results:

  • Comorbidity, disability, and frailty are common in older stroke patients and significantly affect care and outcomes.
  • These age-related conditions require specific assessment and tailored interventions.
  • Existing stroke care models often fail to integrate comprehensive assessments for these complexities.

Conclusions:

  • Stroke care for older adults must systematically address comorbidity, disability, and frailty.
  • Innovations are needed to enhance stroke care pathways for the aging population.
  • Learning from broader geriatric care research can inform better stroke management strategies.

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