Ninth BHD International Symposium: Advancing research through global collaboration.

Area of Science:

• Genetics and Molecular Biology
• Oncology
• Rare Diseases

Background:

• Birt-Hogg-Dubé (BHD) syndrome, also known as Hornstein-Knickenberg syndrome, is a rare genetic disorder.
• The condition is associated with an increased risk of certain tumors, particularly renal cell carcinoma.
• Understanding the molecular mechanisms underlying BHD syndrome is crucial for developing effective treatments.

Purpose of the Study:

• To present and discuss recent research findings on BHD syndrome.
• To foster collaboration among international researchers and clinicians.
• To improve the understanding and management of BHD syndrome.

Main Methods:

• The 9th Birt-Hogg-Dubé (BHD) International Symposium was held virtually in March 2026.
• The symposium featured presentations and discussions on various aspects of BHD syndrome.
• Over 100 international participants attended the virtual meeting.

Main Results:

• Recent genetic insights into BHD syndrome were presented.
• Advances in the molecular understanding of the Folliculin (FLCN) tumor suppressor were discussed.
• New therapeutic strategies and clinical findings were shared, alongside patient experiences.

Conclusions:

• The symposium highlighted significant progress in BHD syndrome research.
• Continued international collaboration is essential for advancing BHD syndrome understanding and care.
• Improved knowledge of FLCN's role may lead to novel therapeutic targets.